J. Matthew Brennan

Matthew Brennan

Interventional Cardiologist

Duke University Medical Center and
Duke Clinical Research Institute (DCRI)

Durham, North Carolina


Dr. Brennan is an Interventional Cardiologist at Duke University Medical Center (DUMC) and faculty member of the Duke Clinical Research Institute, with a clinical and academic interest in the development and evaluation of medical devices. Dr. Brennan is the PI of an ongoing U.S. FDA U01 grant (1U01FD004591-01) developing Medicare claims for health outcomes ascertainment in product surveillance and clinical trial applications. He has substantial experience with both the NCDR CathPCI Registry and he co-directs the analysis center for both the STS Adult Cardiac Surgery Database and the STS/ACC Transcatheter Valve Therapies Registry. He has led comparative device evaluations in collaboration with the U.S. FDA and AHRQ, and is a co-Principal Investigator on a series of TVT Registry sponsored post-market IDE studies for evaluation of expanded clinical use of the Edwards Sapien transcatheter valve device.