Methodology Forum March 4, 2015

March 4, 2015 (2:00-4:00pm EST)

Meeting Contact: wood@hcp.med.harvard.edu

Agenda

2:00 – 2:15 Objectives/Logistics

2:15 – 2:30 Introductions

2:30 – 2:45 Case Study 1: Matthew Brennan (Duke)

2:45 – 3:00 Discussion

3:00 – 3:15 Methods Study: Laura Hatfield (Harvard)

3:15 – 3:30 Discussion

3:30 – 3:45 Next Steps

Summary

  • Forum meetings planned on a quarterly basis
  • Summary of meeting posted on public website
  • Form collaborations
  • What can this group do:
    • Write white papers/participate in public forms
    • Identify common problems and propose solutions
      • Prioritize gaps in key methodological areas
    • 3 problems identified by Dr. Brennan:
      • multiple treatments,
      • missing data,
      • multiple comparisons
    • Dr. Hatfield:
      • Learning curve issues: how handled in post-market setting?
      • Make better use of realistic loss functions (enumerate actions that industry may face, that patients may face, that a regulatory agency may face)