Comparative effectiveness research: does one size fit all?

Journal Statistics in Medicine
Authors Kunz, Lauren M.; Yeh, Robert W.; Normand, Sharon-Lise T.
Year Published 2012
Link to Publication


In this commentary, we argue that although randomization has many benefits, not all questions we seek to answer fit into a randomized setting. Our argument utilizes the clinical setting of carotid atherosclerosis management where specific clinical questions are answered by using a variety of comparative effectiveness designs. Observational studies should not be ruled out when designing studies to address questions of comparative effectiveness.