|Journal||Statistics in Medicine|
|Authors||Kunz, Lauren M.; Yeh, Robert W.; Normand, Sharon-Lise T.|
|Link to Publication|
In this commentary, we argue that although randomization has many benefits, not all questions we seek to answer fit into a randomized setting. Our argument utilizes the clinical setting of carotid atherosclerosis management where specific clinical questions are answered by using a variety of comparative effectiveness designs. Observational studies should not be ruled out when designing studies to address questions of comparative effectiveness.